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Finding the CB3 receptor could mean and huge medical advancements. Originally called GPR55 after the gene that encodes it, the CB3 receptor has been up-ending expectations since researchers found it. Every new finding provides more explanations about the mechanisms by which cannabis works within the body. Cannabinoid receptors are found throughout the body, so where has CB3 been hiding? The two most researched receptors are CB1 and CB2. While CB1 receptors are prominent in the central nervous system, CB2 receptors reside in the immune system. CB3 receptors were hiding incognito as GPR55. At first, science didn't know that this receptor accepted cannabinoids. What is the CB3 Receptor? The CB3 stayed stayed hidden from scientists because it's so unlike the other cannabinoid receptors. It only shares fourteen percent of amino acid identity with them. It simply doesn't look like it would react with cannabis, so scientists on the hunt for new cannabinoid receptors passed over it for years. The alternative name for CB3 is GPR55. It is also identified as an orphan receptor. This designation means that while the receptor has been found, science doesn't yet know what activates that receptor. CB3 was first discovered in 1999, many doubted it was a cannabis receptor. It wasn't until real proof came along years later (finally confirmed through a 2008 study published in the journal PNAS) that medical researchers accepted that GPR55 was actually CB3.[1]Lauckner, Jane E. et al. (2008). GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. PNAS. 105(7) 2699-2704. https://www.pnas.org/content/105/7/2699. jQuery('#footnote_plugin_tooltip_7206_2_1').tooltip({ tip: '#footnote_plugin_tooltip_text_7206_2_1', tipClass: 'footnote_tooltip', effect: 'fade', predelay: 0, fadeInSpeed: 200, delay: 400, fadeOutSpeed: 200, position: 'top center', relative: true, offset: [-7, 0], }); Now, more recent research on the CB3 receptor is ushering in an era of new possibilities that may finally explain the unsolved…

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Source : Unlocking the Medical Potential of the CB3 Receptor

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